THIOCORALINE

Molecular Weight: 1157.41 g/mol
Molecular Formula: C₄₈H₅₆N₁₀O₁₂S₆

Source: Micromonospora marina (Actinomycete bacteria)
Activity: DNA polymerase ± inhibition
Status: Preclinical

Belonging to the chemical family known as the thiodepsipeptides, thiocoraline was first isolated from Micromonospora marina, an actinomycete bacterium collected from coastal Mozambique, southeast Africa.

The Spanish marine drug company PharmaMar has reported that the compound shows activity against several standard drug screens, including breast cancer, colon cancer, renal cancer, and melanoma. Target cells appear to be inhibited through inhibition of DNA polymerase ± enzyme.

The most recent published literature suggests thiocoraline is still undergoing advanced preclinical evaluation.

NCBI PubChem compound summary page - [ LINK ]

NCBI PubMed biomedical literature citations and abstracts - [ LINK ]

References

Newman, DJ, and GM Cragg. 2004. Advanced Preclinical and Clinical trials of natural Products and Related Compounds from marine Sources. Current Medicinal Chemistry 11:1693-1713.