SALICYLIHALAMIDES

Molecular Weight (Salicylihalamide A): 439.544 g/mol
Molecular Formula(Salicylihalamide A): C₂₆H₃₃NO₅

Source: The sponge Haliclona sp. (PORIFERA)
Activity: Vo-ATPase inhibitor
Status: Preclinical

The Vo-ATPases are a group of eukaryotic enzymes whose principal role is to pump hydrogen ions across cell vacuolar membranes. Salicylihalamides A and B, isolated from the sponge Haliclona sp. collected off of Westaen Australia, displays Vo-ATPase inhibitory activity that may eventually be incorporated into a drug designed to target these cell components.

In addition to having potential as anti-tumor compounds, Vo-ATPases like the salicylihalamides may be capable of mediating the process of bone resorption. In this capacity, the compounds might form the basis for treatment of osteoporosis and similar diseases.

NCBI PubChem compound summary pages - [ LINK ]

NCBI PubMed biomedical literature citations and abstracts - [ LINK ]

References

Newman DJ, and GM Cragg. 2004. Advanced Preclinical and Clinical trials of natural Products and Related Compounds from marine Sources. Current Medicinal Chemistry 11:1693-1713.