MANZAMINE A

Molecular Weight: 548.761 g/mol
Molecular Formula: C₃₆H₄₄N₄O

Source: The sponge Haliclona sp. (PORIFERA)
Activity: Demonstrated activity against malaria, tuberculosis, HIV, and others.
Status: Preclinical

NCBI PubChem compound summary pages - [ LINK ]

NCBI PubMed biomedical literature citations and abstracts - [ LINK ]

References

Rao KV, Santarsiero BD, Mesecar AD, Schinazi RF, Tekwani BL, and MT Hamann. 2003. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod 66:823-828.

Sakai R, Higa T, Jefford CW, and G Bernardinelli. 1986. Manzamine A, a Novel Antitumor Alkaloid from a Sponge. J Am Chem Soc 108:6404-6405.

Winkler JD, Londregan AT, and MT Hamann. 2006. Antimalarial activity of a new family of analogues of manzamine A. Org Lett 8:2591-2594.

Yousaf M, Hammond NL, Peng J, Wahyuono S, McIntosh KA, Charman WN, Mayer AM, and MT Hamann. 2004. New manzamine alkaloids from an Indo-Pacific sponge. Pharmacokinetics, oral availability, and the significant activity of several manzamines against HIV-I, AIDS opportunistic infections, and inflammatory diseases. J Med Chem 47:3512-3517.