"DRUGS FROM THE SEA" INDEX

This is a collection of summary information on marine-based natural products of biomedical and/or historical significance. Information provided for each product entry includes compound source, bioactivity, and clinical status, as well as structural and chemical attributes and commercial development highlights.

Analgesia

• Manoalide
• Pseudopterosins
• Ziconotide (Prialt®)

Anti-Alzheimer Agent

• Anabaseine (Hoplonemertine toxin)
• Debromohymenialdisine (DBH)

Anti-Angionegic Agent

• Neovastat® (AE-941) [Preclinical]
• Squalamine

Anti-Asthma Agent

• Contignasterol (IZP-94005, IPL576,092)

Antifungal

• Cryptophycins
• Lasonolides

Anti-Infective Agent

• Manzamine A [Preclinical]

Anti-Inflamatory

• Manoalide
• Pseudopterosins
• Topsentins

Antitumor/Tumor Growth Inhibition

• Bengamides and Derivatives
• KRN7000
• Lasonolides
• Manzamine A [Preclinical]
• Neovastat® (AE-941) [Preclinical]
• Spisulosine
• Squalamine

Apoptosis Induction

• Ecteinascidin 743 (Yondelis®)
• Aplidine (Aplidin®)

Cytotoxins

• Cryptophycins
• Hemiasterlins (H-286)
• Kahalaide F

DNA Polymerase Inhibition

• Thiocoraline [Preclinical]

Gene Inhibition

• Kahalaide F

Immunostimulatory

• KRN7000

Immunosuppressive

• Bryostatin 1

Osteoarthritis Treatment

• Debromohymenialdisine (DBH)

Protein Kinase C Binding Inhibition

• Bryostatin 1

Protein Synthesis Inhibition

• Girolline (Girodazole)
• Didemnin B

Tubulin/Actin Interactive Agents (primarily anti-cancer)

• Cryptophycins
• Curacin A [Preclinical]
• Diazonamide A [Preclinical]
• Dictyostatin [Preclinical]
• Discodermolide
• Dolastatins
• Eleutherobin [Preclinical]
• Halichondrins
• Hemiasterlins (H-286)
• Latrunculins [Preclinical]
• Laulimalide (and Synthetic Analogs) [Preclinical]
• Peloruside A [Preclinical]
• Sarcodictyins [Preclinical]
• Vitilevuamide [Preclinical]

Vo-ATPase Inhibition

• Salicylihalamides [Preclinical]