"DRUGS FROM THE SEA" INDEX

This is a collection of summary information on marine-based natural products of biomedical and/or historical significance. Information provided for each product entry includes compound source, bioactivity, and clinical status, as well as structural and chemical attributes and commercial development highlights.

Microbe-Derived Compounds

• Cryptophycins
• Curacin A [Preclinical]
• Thiocoraline [Preclinical]

Sponge-Derived Compounds

• Bengamides and Derivatives
• Contignasterol (IZP-94005, IPL576,092)
• Debromohymenialdisine (DBH)
• Discodermolide
• Girolline (Girodazole)
• Halichondrins
• Hemiasterlins (H-286)
• KRN7000
• Lasonolides
• Manoalide
• Topsentins
• Dictyostatin [Preclinical]
• Latrunculins [Preclinical]
• Laulimalide (and Synthetic Analogs) [Preclinical]
• Manzamine A [Preclinical]
• Peloruside A [Preclinical]
• Salicylihalamides [Preclinical]

Cnidarian-Derived Compounds

• Pseudopterosins
• Eleutherobin [Preclinical]
• Sarcodictyins [Preclinical]

Helminth-Derived Compounds

• Anabaseine (Hoplonemertine toxin)

Molluscan-Derived

• Dolastatins
• Kahalaide F
• Spisulosine
• Ziconotide (Prialt®)

Bryozoan-Derived Compounds

• Bryostatin 1

Ascidian-Derived Compounds

• Aplidine (Aplidin®)
• Didemnin B
• Ecteinascidin 743 (Yondelis®)
• Diazonamide A [Preclinical]
• Vitilevuamide [Preclinical]

Vertebrate-Derived Compounds

• Squalamine
• Neovastat® (AE-941) [Preclinical]